Homologous recombination between HERVs causes duplications in the AZFa region of men accidentally exposed to cesium-137 in Goiânia
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چکیده
منابع مشابه
Homologous recombination between HERVs causes duplications in the AZFa region of men accidentally exposed to cesium-137 in Goiânia.
In September 1987, in Goiânia, Brazil, one of the most serious radiological accidents occurred at a radiation therapy unit involving a source of cesium-137. The current study examined the occurrence of possible germline mutations at the AZF region of the exposed men and in their male offspring. Genomic DNA samples of 16 individuals were analyzed for microdeletions. All exposed individuals ampli...
متن کاملDuplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility.
Deletions of the AZFa region on the long arm of the human Y chromosome cause male infertility. Previous work has shown that this is an example of a genomic disorder, since most deletions are caused by non-allelic homologous recombination between endogenous retroviral elements (HERVs) flanking the 780 kb region. The reciprocal products of these deletion events, AZFa duplications, have not been r...
متن کاملSystemic Arterial Hypertension in Patients Exposed to Cesium-137 in Goiânia-GO: Prevalence Study
Background: Systemic Arterial Hypertension (SAH) in the Brazilian population, in populations not exposed to Césio-137, presents a prevalence of 28% nationwide. However, in the group of radioactivity victims, these values are unknown. Objective: To analyze the prevalence of hypertension in patients exposed to Cesium-137 in Goiânia, enrolled in the Sistema de Monitoramento dos Radioacidentados ...
متن کاملThe effect of low-dose exposure on germline microsatellite mutation rates in humans accidentally exposed to caesium-137 in Goiânia.
A serious radiological accident occurred in 1987 in Goiânia, Brazil, which lead to extensive human and environmental contamination as a result of ionising radiation (IR) from caesium-137. Among the exposed were those in direct contact with caesium-137, their relatives, neighbours, liquidators and health personnel involved in the handling of the radioactive material and the clean-up of the radio...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2008
ISSN: 1676-5680
DOI: 10.4238/vol7-4gmr492